Paul O'Connell made a successful return in Munster's workmanlike RaboDirect PRO12 win over the Newport Gwent Dragons.
Ospreys welcome back Justin Tipuric for their clash with Connacht, while Paul O'Connell is named on Munster's bench.
Munster were knocked off the top of the table as they suffered a shock 29-19 defeat away at Benetton Treviso.
Leigh Halfpenny will make his first appearance for Cardiff this season while Munster look to make history in Italy.
A second-half resurgence from Munster ensured a 43-21 victory and denied Zebre their first ever RaboDirect Pro12 win.
Round two of RaboDirect Pro12 begins with four Friday fixtures featuring Munster, Cardiff Blues, Ulster and the Dragons.
Munster outscored an under-strength Edinburgh team by five tries to two in Cork as they claimed a 34-23 victory.
BJ Botha has been ruled out for the opening month of Munster's season after suffering a medial ligament tear.
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