Paul O'Connell made a successful return in Munster's workmanlike RaboDirect PRO12 win over the Newport Gwent Dragons.
Ospreys welcome back Justin Tipuric for their clash with Connacht, while Paul O'Connell is named on Munster's bench.
Dragons hooker Rhys Thomas has been ruled out until next year after suffering an ankle injury.
Dragons continued their fine start to the Pro12 campaign by securing a 23-16 win in a Welsh derby against the Scarlets.
Second row forward Ian Nimmo has signed a loan agreement with London Irish.
Leigh Halfpenny will make his first appearance for Cardiff this season while Munster look to make history in Italy.
A last-gasp penalty by Harry Leonard earned Edinburgh a much-needed win over bogey team Newport Gwent Dragons 16-13.
Round two of RaboDirect Pro12 begins with four Friday fixtures featuring Munster, Cardiff Blues, Ulster and the Dragons.
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