Ryan Jones has suffered a new injury setback and is ruled out of making his comeback against Ulster on Friday.
Harlequins captain Chris Robshaw is ready for the challenge presented by the Heineken Cup.
The Ospreys joined Glasgow at the top of the RaboDirect PRO12 table after a 43-26 victory over Connacht in Galway.
Ospreys welcome back Justin Tipuric for their clash with Connacht, while Paul O'Connell is named on Munster's bench.
Ospreys star Tom Smith looks set for another lengthy spell on the sidelines after injuring his knee against Edinburgh.
The unbeaten Ospreys scored six tries as they powered to a 44-10 RaboDirect PRO12 victory over Edinburgh in Swansea.
Geoff Cross and Aleki Lutui will start their first Edinburgh match of the season against Ospreys at the Liberty Stadium.
Ospreys have announced the signing of scrum-half Phil Mack as cover for the injured Rhys Webb and Tom Habberfield.
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