Holders AZ Alkmaar and 18-time winners Ajax survived scares to progress in the KNVB Beker with 4-1 and 4-2 wins.
PSV Eindhoven slipped to their first Eredivisie defeat of the season at AZ Alkmaar, while Ajax thrashed Go Ahead Eagles.
PSV Eindhoven stunned Ajax as they routed the defending champions 4-0 to climb to the top of the Eredivisie standings.
Ajax coach Frank de Boer has talked up his team's chances of victory in this weekend's high-profile game against PSV.
PSV Eindhoven went down to a shock 2-0 home defeat in their Europa League Group B opener against Ludogorets.
Ajax inflicted a first defeat on Eredivisie leaders PEC Zwolle on Saturday, while FC Twente held PSV Eindhoven.
PEC Zwolle face the stiffest test of their season as they visit reigning Eredivisie champions Ajax on Saturday.
PSV Eindhoven passed up the chance to move top of the Eredivisie as they were held to a 0-0 home draw by Cambuur.
Real Sociedad are through to Champions League group stage after a 4-0 aggregate win over Lyon, while Milan thrash PSV.
Manchester United have enquired over the availability of Memphis Depay, Dutch champions PSV have revealed.
Massimiliano Allegri wants AC Milan to attack PSV Eindhoven in the Champions League.
Marco van Basten will put his past with Ajax to one side when the champions visit the Abe Lenstra Stadion.
PSV midfielder Georginio Wijnaldum says he has no intention of leaving the club, despite reported interest from Arsenal.
AC Milan earned a 1-1 draw with PSV Eindhoven in their Champions League play-off round tie.
Tim Matavz says that he would be open to an exit from PSV at some point in the future.
Three second-half goals saw PSV Eindhoven defeat Go Ahead Eagles and make it a hat-trick of wins in the Eredivisie.
Feyenoord will do everything possible to make sure Samuel Armenteros is available for their Eredivisie clash with Ajax.
PSV Eindhoven defender Jorrit Hendrix is delighted to have signed a new four-year contract with the Eredivisie club.
Hannover have confirmed the signing of Brazilian defender Marcelo from Dutch side PSV Eindhoven on a four-year deal.