AZ Alkmaar have confirmed the shock departure of coach Gertjan Verbeek - despite overseeing victory over PSV Eindhoven.
Holders AZ Alkmaar and 18-time winners Ajax survived scares to progress in the KNVB Beker with 4-1 and 4-2 wins.
PSV Eindhoven slipped to their first Eredivisie defeat of the season at AZ Alkmaar, while Ajax thrashed Go Ahead Eagles.
PSV Eindhoven stunned Ajax as they routed the defending champions 4-0 to climb to the top of the Eredivisie standings.
Johann Berg Gudmundsson scored the only goal as AZ Alkmaar picked up an impressive win at Maccabi Haifa in their Europa League Group L clash.
Three men were sent off as Heerenveen beat FC Groningen 4-2, while struggling Feyenoord salvaged a 3-3 draw at Nijmegen.
PEC Zwolle face the stiffest test of their season as they visit reigning Eredivisie champions Ajax on Saturday.
PEC Zwolle's 100 per cent winning start to the Eredivisie season ended after they drew 1-1 at home to FC Utrecht.
AZ Alkmaar's Europa League play-off at home to Atromitos was abandoned after a fire broke out at the AFAS Stadion.
Feyenoord won 3-1 against NAC Breda while Utrecht secured all three points by beating AZ Alkmaar 2-0.
Marco van Basten will put his past with Ajax to one side when the champions visit the Abe Lenstra Stadion.
There were wins for wins for Sevilla, Fiorentina and Rubin Kazan on Thursday evening in the Europa League.
Three second-half goals saw PSV Eindhoven defeat Go Ahead Eagles and make it a hat-trick of wins in the Eredivisie.
Feyenoord will do everything possible to make sure Samuel Armenteros is available for their Eredivisie clash with Ajax.
Feyenoord lost 4-1 to FC Twente while Ajax went down 3-2 to AZ Alkmaar in Sunday's Eredivisie action.
Ajax's Viktor Fischer is delighted at the way the Eredivisie champions' coach Frank de Boer encourages him to play.
PSV Eindhoven opened their Eredivisie campaign with a nervy 3-2 win at ADO Den Haag, while FC Groningen thrashed NEC.
Siem De Jong scored in extra time as as Ajax came from two goals down to beat AZ Alkmaar 3-2 in the Johan Cruyff Schaal.
Sky Sports understands a number of English clubs are tracking AZ Alkmaar winger Johann Berg Gudmundsson.
Jozy Altidore has undergone a medical at Sunderland's training ground ahead of his proposed move.